The pathogenesis of lupus erythematosus(LE) appears to be multifactorial, including genetic, hormonal and environmental influences. Genetic factors have long been suspected to an important role in its pathogenesis. This has been shown in family
studies
and twin studies.
We report a family in which mother developed SLE and son developed DLE. The mother, 35 year old female, had hyperpigmented brownish macules and atrophic scars on the face and also complained of fever, chill and arthralgia for 2 years. The
clinical,
laboratory and histopathological findings showed characteristic features of systemic lupus erythematosus. She had been treated with systemic prednisolone, hydroxychloroquin sulfate and topical corticosteroid ointment for about 4 years resulting
favorable improvement skin lesions. Laboratory studies during her course had demonstrated persist leukopenia, speckled pattern ANA and VDRL positive.
The son, 10-year-old, had pea sized, multiple erythematous papules and plaques on the face and arms for 2 months. The clinical, laboratory and histopathologi-cal findings showed characteristic features of discoid lupus erythematosus.
He was treated with systemic prednisolone for 2 years, hydroxychloroquin sulfate and topical corticosteroid ointment for about 4 years resulting nearly all clearing of skin lesions with slighthly hyperpigmentation. Laboratory studies during his
course
had demonstrated only weakly ANA positive. (Kor J Dermatol 1995;33(5) : 950~955)
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